Chiral Separation by Inclusion Complexes

3 Chiral Separation by k-k Interactions, Hydrogen Bonding, and Ion Pairing 

The cinchona alkaloid-based stationary phases are chiral stationary phases where quinine/ quinidine are chemically bonded to a silica gel matrix. The interaction between the selectand and selector is based on charge transfer n-n interactions as well as ion pairing with the selector. They operate under aqueous-organic mobile phases or mixtures of organic solvents such as hexane-alcohols. 

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