Chiral monophosphine catalytic asymmetric hydrogenation

Catalytic asymmetric synthesis, in particular, hydrogenations, C-C bond formations, and tautomerizations, rely to a great extent on chiral 6frphosphines (Scheme 1—43) rather than on monophosphines as catalyst ligands. DIPAMP [l,2-ethylenebis(o-anisylphenylphosphine), 56] belongs to the rare examples where chirality resides directly at an asymmetric phosphorus atom (Scheme 1-43). More often enantiodiscrimination originates from carbon stereocenters, as present in DIOP " [2,2-dimethyl-1,3-dioxolane-... 

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