Chiral compounds Organotitanium reagents

E. Enantioselective Addition of Chirally Modified Organotitanium Reagents to Carbonyl Compounds... 

Complete details are available concerning stereoselective addition of these reagents to chiral aldehydes or ketones and of crotyltitanium compounds to carbonyl groups (12, 354).2 The most diastereoselective additions to cyclohexanones known to date are effected with organotitanium reagents. 

However, in a comprehensive study, Seebach and coworkers have shown the usefulness of titanium and zirconium alkyls as selective nucleophilic reagents.106,107 Typically compounds of the type (RO)3MR (M = Ti, Zr) are reacted with aldehydes or ketones to yield asymmetric alkoxides (equation 32),107 The method has been extended to allow enantioselective addition using chiral organotitanium reagents where the chirality is imposed by the initial alkoxide substituents.107,108... 

---