Chiral Anti prism

Formation of trigonal prismatic 5.50 and 5.51 (reproduced with permission from reference 

Illustration of right- (P) and left- (M) handed chirality of cage 5.50 (from reference ). 

Two diastereomeric complexes were observed in solution when (/ )-mandelic acid was added, suggesting that racemization of one diastereomer to the other, which would involve cleavage of two Pd-N bonds, does not take place on the NMR time scale. When racemic mandelic acid was added, diastereomers were not observed. This suggests that the (R) and (S) forms of the guest exchange quickly from one host enantiomer to the other, showing the host enantiomers to be spectroscopically identical. 

Illustration of the conformational change in cage 5.52 upon guest encapsulation (adapted with permission from reference ). 

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