Chimeric gene

Chapter 13 Recombinant DNA Cloning and Creation of Chimeric Genes... 

Herrera-Estrella L, Depicker M, Van Montagu M, Schell J (1983) Expression of chimeric genes transferred into cells using a Ti-plasmid-derived vector. Nature 303 209-213... 

Volume 326. Applications of Chimeric Genes and Hybrid Proteins (Part A Gene Expression and Protein Purification)... 

These conditions are associated with high renin and high aldosterone production. The hybrid corticosteroids 18-OHF, 18-oxo-F and 18-oxo-THF were isolated from the urine of a patient with adrenal adenoma by Ulick and coworkers [11]. These steroids were subsequently also shown to be dominant in GRA. Their formation in the latter condition was explained by Lifton and co-workers [51] with the discovery of a chimeric gene formed crossover of the 1 1//-hydroxylase (CYPllfil) and aldosterone synthase (CYP11B2) genes. 

Fig. 3.1. Evolution of genes by DNA shuffling. Homologous recombination of evolutionarily related genes creates a library of chimeric genes. Some genes from related species are shuffled to create an even larger pool of novel genes.

Howard, E.A., Walker, J.C., Dennis, E.S. Peacock, W.J. (1987). Regulated expression of an alcohol dehydrogenase-1 chimeric gene introduced into maize protoplasts. Planta 170, 535-40. 

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