Chida’s synthesis of -pironetin

The Nysted reagent (696) 2 jg commercially available, and it reacts with aldehydes or ketones in the presence of BF3 etherate to give an alkene. Reaction with 2-phenylpropanal, for example, gave an 82% yield of 697.5 3 The Takai reactionist uses MeCHl2 in the presence of CrCl2 to generate the alkene. An example is taken from Chida s synthesis of pironetin in which aldehyde 698 was converted to 699 in 74% yield as an 11 1 mixture of (ElZ) isomers.iSS... 

---

See also in sourсe #XX -- [ , , ]

See also in sourсe #XX -- [ , ]

---