Chemotherapy-induced

NADPH quinone oxido-reductase 1 Pro187Ser variant occurring with about 5% frequency is functionally almost completely deficient. Impaired activity associated with benzene toxicity and cancer chemotherapy induced leukemia. 

For prophylaxis of acute chemotherapy-induced nausea and vomiting, the combination of a 5-HT3 antagonist and a corticosteroid is recommended for patients receiving highly eme-togenic cisplatin or non-cisplatin-based chemotherapy. 

CINV, chemotherapy-induced nausea and vomiting PONV, postoperative nausea and vomiting. 

Groopman JE, Itri LM. Chemotherapy-induced anemia in adults Incidence and treatment. J Natl Cancer Inst 1999 91(19) 1616-1634. 

TABLE 87-8. Pharmacotherapy for Chemotherapy Induced Nausea and Vomiting... 

Neumega Oprelvekin Genetics Institute Prevention of severe chemotherapy-induced thrombocytopenia... 

NEUPOGEN Filgrastim (G-CSF) Amgen Chemotherapy-induced neutropenia, bone marrow transplantation, chronic severe neutropenia, peripheral blood progenitor cell transplant... 

Tortorice P and O Connell M (1990). Management of chemotherapy-induced nausea and vomiting. Pharmacotherapy, 10, 129-145. 

NK1 agonist-mediated gerbil foot tapping model (ID50 = 0.33 mpk) [34]. Aprepitant (36), which contains seven fluorine atoms, was subsequently approved by the Food and Drug Administration (FDA) for the prevention of acute and delayed chemotherapy-induced nausea and vomiting. 

Esser, M. and Brunner, H. 2003. Economic evaluations of granulocyte colony stimulating factor in the prevention and treatment of chemotherapy-induced neutropenia. Pharmacoeconomics 21(18), 1295-1313. 

C-ll, C-lll, C-IV, controlled substance schedule 2, 3, and 4, respectively cap, capsule chew tab, chewable tablet CINV, chemotherapy-induced nausea and vomiting liquid, oral syrup, concentrate, or suspension OTC, nonprescription Rx, prescription supp, rectal suppository tab, tablet. 

Dexamethasone has been used successfully in the management of chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV), either as a single agent or in combination with selective serotonin reuptake inhibitors (SSRIs). For CINV, dexamethasone is effective in the prevention of both cisplatin-induced acute emesis and when used alone or in combination for the prevention of delayed nausea and vomiting associated with CINV. 

Libura, J. et al., Risk of chemotherapy-induced pulmonary fibrosis is associated with polymorphic tumour necrosis factor-a2 gene, Eur. Respir. J., 19, 912, 2002. 

Severe thrombocytopenia and reduction of the need for platelet transfusions Chemotherapy-induced thrombocytopenia Nov. 1997... 

Chemotherapy-induced neutropenia Neutropenia during bone marrow transplant Severe chronic neutropenia Autologous or allogeneic bone marrow transplantation Mobilization of autologous PBPCs after chemotherapy Persistent or recurrent cutaneous T cell lymphoma Feb. 1991 June 1994 Dec. 1994 Dec. 1995 April 1998 Feb. 1994... 

Aranesp, Darbepoetin alfa Amgen, Inc. Anemia associated with chronic renal failure Chemotherapy-induced anemia in patients with non-myeloid malignancies Sept. 2001 July 2002... 

The present review covers progress in medical chemistry, basic mechanisms of emesis, role of serotonergic mechanism, and treatment of cancer-chemotherapy-induced emesis. 

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