Chemistry Applications on a Solid Phase CCSP

Combinatorial Chemistry Applications on a Solid Phase (CCSP) 

CCSP can be used in numerous types of organic reactions. Some of the appHca-tions are outlined below. 

Immobilization of the required dioxolane-protected 4-Hthioacetophenone, deprotection with pyridinium p-toluene sulphonate (PPTS), and condensation with Bredereck s reagent gave resin-bound enaminone 2. The suitability of resin 2 for H-brary synthesis was verified by a trial condensation with acetamidine hydrochlori- 

02-mmol scale. The resulting pyrimidines were released from the resin in a traceless fashion using TFA. 

The methods for oligomerization of the peptoid monomers are broadly based on the techniques developed for solid-phase peptide synthesis. A number of modifications are necessary, since difficulties are often encountered with N-alkyl amino acids for example, proHne and other N-alkylamino acids often couple poorly under standard conditions. Currently a wide range of functionalized polystyrenes and polystyrene copolymers is available. The immobilized functional group typically is an amino, carboxy, halo, hydroxy, or phosphino group. The polymer is joined to the 

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