Chemico-enzymatic synthesis

Shoji A, Hasegawa T, Kuwahara M et al (2007) Chemico-enzymatic synthesis of a new fluorescent-labeled DNA by PCR with a thymidine nucleotide analogue bearing an acridone derivative. Bioorg Med Chem Lett 17 776-779... 

V. N. Shibaev, T. N. Druzhinina, L. M. Gogilashvili, N. K. Kochetkov, S. S. Rozhnova, and V. A. Kilesso, Chemico-enzymatic synthesis of glucosylated O-specific polysaccharides of Salmonella, Dokl. Akad. Nauk SSSR, 270 (1983) 897-899. 

As an example of use of the chemico-enzymatic approach,the synthesis of the S. anatum polysaccharide (24) which consists of trisaccharide I units joined by eC-galactosyl-1— 6-mannose linkages, will be discussed. 

A chemico-enzymatic approach has been used for the synthesis of Coenzyme A analogues, modified in the thioethanolamine unit, using ATP as one starting material. Pyrophosphate bond formation from a nucleoside 5 -phosphorimidazolide catalysed by divalent metal ions (Mn2+, Cd + or Mg2+) has been used to make dinucleoside di- and tri-phosphates such as CppC and GpppG. A vanadate analogue of NADP is mentioned in Chapter 16, in connection with its ability to function as a redox cofactor. 

Yokozeki K, Eguchi C, Kamimura A, Kubota K (1988) Asymmetric synthesis of S-carboxymethyl-L-cysteine by a chemico-enzymatic method. Agric Biol... 

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