Chemicals with Antiestrogenic Activity Xenoantiestrogens

In contrast to substances which exert estrogen-Hke activity, a variety of nonsteroidal chemicals possess antiestrogenic activity. These chemicals are also named antiestrogens or xenoantiestrogens. The term antiestrogen can be applied to several classes of chemicals that modify, modulate, inhibit, or antagonize the actions and effects of natural estrogens. These include 

The polycyclic aromatic hydrocarbons (PAHs) encompass a further group of environmental chemicals with antiestrogenic activity. Examples are benzo[a] pyrene, benz[a]anthracene, 3-methyl-cholanthrene, and 7,12-dimethylbenz[a] anthracene [120b]. 

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