Chemically modified signal generation

Figure 8.6 Schematic representation of a biomolecular-nanoparticle supramolecular assembly consisting of double-stranded DNA (ds-ODN) modified electrodes for the capture of p53 protein. Electrochemical signal generation and amplification occurred by subsequent labeling of the p53 tetramer with biotin (Biotin-Mi) and capture of streptavidin-modified Fc-capped AuNPs.26 (Reprinted with permission from J. Wang et al., Anal. Chem. 2008,80,769 -774. Copyright 2008 American Chemical Society.)...

The immobilization of a photoisomerizable material that can be switched by light between redox-active and redox-inactive or conductive and insulating states offers an encouraging route toward integrated molecular memory devices. Figure 7.2 shows a photoisomer state A in which the molecular unit is redox-inactive and no electronic signal is transduced. Photoisomerization of the chemical component to state B generates a redox-active assembly, and the electron transfer between the electrode and the chemical modifier yields an amperometric (electrochemical) indicator of the state of the system. 

Figure 5.7 Signal generation at a chemically modified electrode.

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