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Chemical safety ligand

Fig. 6. Chemical feature similarities between whole activity classes for the targets used in predinical safety profiling. Black colors indicate high class similarities, whereas grey colors show low similarities. We compute similarity by using the Pearson correlation of normalized feature probabilities in each Bayesian model. Notably, receptor families share ligand similarity, as would be expected however, non-family pairing also share features, such as antihistamines (H1 receptor) and hERG blockers (in agreement with the arrhythmia that can be caused by this class of compounds). Fig. 6. Chemical feature similarities between whole activity classes for the targets used in predinical safety profiling. Black colors indicate high class similarities, whereas grey colors show low similarities. We compute similarity by using the Pearson correlation of normalized feature probabilities in each Bayesian model. Notably, receptor families share ligand similarity, as would be expected however, non-family pairing also share features, such as antihistamines (H1 receptor) and hERG blockers (in agreement with the arrhythmia that can be caused by this class of compounds).
Shell was the first company to utilize cyclic trialkylphosphines for optimization of Co catalysts [13]. Meanwhile, these ligands are commercially available as a mixture under the collective chemical name phobanes. Bungu and Otto [14] evaluated various venues to phobanes by taking yields and safety issues into consideration. Differences in the methods consisted mainly in the employment of... [Pg.80]


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Chemical safety

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