Chemical exposure mammalian organism

The toxicokinetic profile of a chemical warfare agent in mammalian organisms depends on numerous factors, including the nature of the poison, route of exposure, and species differences. Sophisticated study design, modem technical and analytical monitoring tools as well as reliable data from literature are indispensable quality criteria which should be met when performing toxicokinetic studies. The present chapter is focused on this topic. For guidance, we will comment on the stracture of this chapter to provide the reader with an impression of the content. 

Extensive evidence conclusively demonstrates that another important mechanism of action of adrenotoxicants is the generation of ROS and the imbalance between prooxidants and antioxidants in the cell. The resulting oxidative stress is a mechanism mediating the toxic effects of numerous chemicals in a wide array of cells and organs, in many if not all, animal and plant species. Numerous studies with mammalian models using either in vitro exposures of tissues and cells or whole animal studies,... 

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