Chemical entity formatting format overview

Severai detaiied reviews on the stabiiity of proteins and protein pharmaceuticais written for pharmaceutical scientisls are available (43,45,46,47,48,49,50). A brief overview of these resources foiiows and provides additionai information. The instability of proteins, including protein pharmaceuticals, can be separated into two distinct ciasses. Chemicai instabiiity resuits from bond formation or cleavage yielding a modification of the protein and a new chemical entity. Physical instability involves a change to the secondary or higher-order structure of the protein rather than a covalent bond-breaking modification. 

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