Chemical delivery systems, blood-brain barrier

Dmg loading in micro- and nanoparticulate systems is generally carried out by one of two methods, i.e. during the preparation of particles (incorporation) or after their formation (incubation). The dmg delivery properties are also essentially dependent on the chemical and textural properties of the matrices, the porosity, wettability, erosion and the surface area. The matrix equally has an impact on the discharge profile for the bioavailability of the entrapped dmg. Nanoparticle-based delivery systems have the potential power to improve dmg stability, increase the duration of the therapeutic effect and permit enteral or parenteral administration, which may prevent or minimize dmg degradation and metabolism as well as cellular efflux [70, 71]. Protein nanoparticles can conveyance medications transversely across the blood-brain barrier that are not usually passed across after injection. A number of authors have demonstrated a considerable tendency for an accumulation of protein nanoparticles in certain tumours. The binding of a variety of cytotoxic dmgs, such as 5-fluorouracil,... 

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