Chemical arrays fabrication strategies

To date, several tactics and strategies have been described for the fabrication of chemical arrays. These strategies can be classified in the following manner based on how small molecules are introduced into the array (1) site-specific covalent immobilization, (2) site-nonspecific covalent immobilization, (3) site-specific... 

Based on these considerations, a great deal of current research on SERS has focused on the controlled and reproducible fabrication of metallic nanostructures that produce hot spots in which the molecules are appropriately and predictably located for large Raman enhancement. Several strategies have been proposed for engineering such hot structures for chemical sensing applications in a reproducible and controllable manner. These include structures such as triangular nanoparticle array [30], silver nano wire bundles [31, 32], Ag nanoparticle-assembled silica... 

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