Chelating agents and therapy

Hahn, E. Rupprecht, S. Kramp, W. Nenmeier, R. Preparation of poly(aryloxyalkyl)amine chelating agents and their technetinm and rheninm complexes for diagnosis and therapy. Ger. Offen. DE 4025788, 1992 Chem. Abstr. 1992,117, 130916. 

Palmer 1989 Robinson et al.1983). However, the ratio was almost certainly affected by initial chelation with Ca-DPTA, followed by daily intravenous therapy with the chelating agent, Zn-DPTA, treatments that would have increased the urinary excretion of americium (Breitenstein and Palmer 1989). The above not withstanding, the observations made on this subject demonstrate that fecal excretion was an important pathway of excretion in this subject long after mechanical clearance of americium from the respiratory tract would have been complete. This is consistent with observations made in nonhuman primates that show that americium is excreted into bile (see Section 3.4.4.4). However, the extent to which the biliary excretion pathway in humans might resemble that of nonhuman primates is not known. 

Domingo, J.L. (2006) Aluminium and other metals in Alzheimer s disease a review of potential therapy with chelating agents. J. Alzheimer Dis., 10, 331-341. 

For patients who are unable to tolerate penicillamine, trientine, another chelating agent, may be used in a daily dose of 1-1.5 g. Trientine appears to have few adverse effects other than mild anemia due to iron deficiency in a few patients. Zinc acetate administered orally increases the fecal excretion of copper and is sometimes used for maintenance therapy. The dose is 50 mg three times a day. Zinc sulfate (200 mg/d orally) has also been used to decrease copper absorption. Zinc blocks copper absorption from the gastrointestinal tract by induction of intestinal cell metallothionein. Its main advantage is its low toxicity compared with that of other anticopper agents, although it may cause gastric irritation when introduced. 

In this way, by reducing permeability barriers, combination therapy with antibiotic and chelating agent may enhance significantly the efficacy of suitable antibiotics in the topical treatment of local infection. 

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