Charcot-Marie-Tooth disease CMT

Primary Demyelination and Hypomyelination in the PNS Charcot-Marie Tooth Diseases (CMT)... 

Sereda MW, Meyer zu Horste G, Suter U, Uzma N, Nave KA (2003) Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-IA). Nat Med 9 1533-1537... 

The figure below shows a pedigree that includes individuals with Charcot-Marie-Tooth disease (CMT), a neurologic disorder that produces dysfunction of the distal extremities with characteristic footdrop. If individual 111-4 becomes pregnant, what is her risk of having a child with CMT ... 

In another family with Charcot-Marie-Tooth disease (CMT), restriction analysis using sites flanking the CMT gene on 17 yields one large abnormal fragment and one smaller fragment that is seen in controls. What is the probable inheritance mechanism in this family ... 

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See also in sourсe #XX -- [ , ]

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