Characterization of Protein Conformation in an Oligomer-Specific Fashion

1 Characterization of Protein Conformation in an Oligomer-Specific Fashion 

Equally important, the top-down HX-MS analysis carried out by Konamann and coworkers [30]. revealed the backbone protection pattam of Ap(l-42) oUgomCTS, without any contribution from monomers (a task that could not be accomplished by the classical bottom-up approach, since oligomers and monomers coexist in solution at equilibrium). A similar approach was used by Borchers and coworkers to characterize conformational dynamics of oxidized forms of calmodulin coexisting at equilibrium with intact (unmodified) polypeptide species in solution [32]. 

2 Characterization of Protein Dynamics in a Conformer-Specific Fashion 

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