Peptides channel-forming

Bechinger, B. Structure and functions of channel-forming peptides Magainins, cecropins, melittin, and alamethicin. /. Memhr. Biol. 1997, 756, 197-211. 

Cook, G. A. Prakash, O. Zhang, K. Shank, L. P. Takeguchi, W. A. Robbins, A. Gong, Y. Iwamoto, T. Schultz, B.D. Tomich, J.M. (2004) Activity and structural comparisons of solution associating and monomeric channel-forming peptides derived from the glycine receptor M2 segment Biophys. J. 86,... 

Another even more intensively studied example is alamethicin (Aim), an a-helical channel-forming peptide that forms voltage-activated ion channels in lipid bilayers. It consists of 20 amino acids and exists as two major variants ... 

Two molecules of the ion-channel-forming peptide gramicidin, which contains alternating L- and D-amino acids, have been shown to form a membrane-spanning P-helix. The alternation of L- and D-amino acids is a feature of a series of cyclic peptides that self-assemble into membrane spanning nanotubes. P-Helices have now also been shown to occur as a structural element in proteins consisting only of L-a-amino acids, viz. in the enzyme pectate lyase. Related to the naturally... 

Channel-Forming Peptides in Uniformly Aligned Multilayers of Membranes... 

Finally, we shall emphasize the successful developments of retro-in-verso (all-D-retro) and end group-modified retro-inverso peptides in several biological areas including hormones [104,105], antibody recognition [106-109], peptide vaccines [110], MHC class II presentation [111,112], protein surface and receptor mimicry [113-115], antibacterial and channel-forming peptides such as mellitin and cecropin A [116,117], intracellular delivery systems [118], and nuclear import [119]. 

VL Dorman, S Garofoli, PC Jordan. In DJ Chadwick, G Cardew, eds. Gramicidin and Related Ion-Channel Forming Peptides. Chichester, UK John Wiley, 1999, pp 153-169. 

Alamethicin [Trichoderma viride] 1964.33 methanol channel-forming peptide ionophore for monovalent cations H >Cs =Rb =Na =Li ... 

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