Change in binding of hydrogen ions

Calculation of the Binding of Hydrogen Ions by Reactants and the Changes in Binding of Hydrogen Ions in Biochemical Reactions... 

The change in binding of hydrogen ions in the biochemical reaction is given by... 

CALCULATION OF THE BINDING OF HYDROGEN IONS BY REACTANTS AND THE CHANGES IN BINDING OF HYDROGEN IONS IN BIOCHEMICAL REACTIONS... 

If K increases with pH, ArNH is negative, which indicates that less hydrogen is bound by products than reactants. In this case H+ is produced by the reaction. The change in binding of hydrogen ions in a biochemical reaction can also be... 

Figure 4.6 Plot of the change in binding of hydrogen ions in the reaction ATP + H20 = ADP + Pj at / = 0, 0.10 and 0.25 M at 298.15 K. The more curved plot is at zero ionic strength. (See Problem 4.5.)...

The change in binding of hydrogen ions in the dissociation of the site-L-tartrate complex can be calculated by taking the derivative of log K with respect to pH (equation 4.7-5). The pH dependence of ArNH is shown in Fig. 7.6. 

The changes in binding of hydrogen ions in five biochemical half reactions are shown in Fig. 9.4. Since 8E °/dpH is always negative for a half-reaction, Ar/VH is... 

Equation 10.2-7 shows that there are three contributions to the transformed enthalpy of reaction in this case the effects of the standard enthalpies of formation of the species, the effect due to the change in binding of hydrogen ions, and the... 

The subscripts on the partial derivatives have been omitted because they are complicated, as indicated by the fundamental equation. The change in binding of coenzymes in a reaction can be studied at constant concentrations of coenzymes, just as the change in binding of hydrogen ions in a reaction can be studied at constant pH. The further transformed enthalpy H" of the system can be calculated by use of the Gibbs-Helmholtz equation or from G" = II" — TS". 

Biochemical reactions are different from chemical reactions in that they may produce or consume non-integer amounts of hydrogen ions. This is discussed in terms of the change in binding of hydrogen ions a NH in a biochemical reaction, which is given by... 

Thus the changes in binding of hydrogen ions and magnesium ions are reciprocal effects. 

For reactions for which standard enthalpies of formation of species are known, the preceding chapter shows that dAi H °/3pH and dAr S /3pH can be calculated in two ways directly and from the change in binding of hydrogen ions with temperature. This provides a check on the calculations and it provides an explanation of the magnitudes of these derivatives. 

So the change in binding of hydrogen ions in a redox reaction is the difference between the changes in the two half reactions. Higher derivatives yield dA,// ° /dpH, and dA,S ° /dpH. 

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