Cerebrosides fruiting-inducing

Figure 10 a-Amino acids as starting materials. Synthesis of (S)-8-hydroxyhexadecanoic acid, (5)-4-dodecanolide, fruiting-inducing cerebroside of Schizophyllum commune (Sch II), (5S,4S)-4-methyl-3-heptanol, and (—)-invictolide. 

After completion of the synthesis of Sch II (128) in 1985, we continued our studies on the cerebro-sides inducing the fruiting-body formation in Schizophyllum commune, and the cerebrosides shown in... 

The reason why these cerebrosides induce fruiting-body formation of S. commune is not yet clear. 

Figure 5.9 Synthesis of Whe II, a cerebroside isolated from wheat grain with fruiting-body inducing activity against Schizophyllum commune...

Based on the evidence of positive and negative ion mode FAB MS, the structure of cerebroside (1) was determined to be (4E,8E)-N-2-hydroxyhexadecanoyl-l-0-P-gluco-pyranosyl-9-methyl-Ci8-sphinga-4,8-dienine (Fig. 1), which had been isolated from Schizophyllum commune by Kawai and Ikeda [8] as a fungal fruiting body inducer. 

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