Cerebral perfusion imaging , transition

Multiple parameters can be calculated with CT perfusion imaging of the brain and include cerebral blood flow, cerebral blood volume, time-to-peak, and mean transit time (Wintermark etal.,2006). 

The apphcation of CTP was first proposed as early as 1980 by Axel [20] however, the acquisition and processing systems available in the 1980s were too slow to make CTP a practical tool. The general principles underlying the computation of perfusion parameters such as cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (M lT) are the same for both MR and CT the overall clinical applicability of perfusion imaging using both of these modalities is likely to be similar, hi addition, as will be discussed, first pass CTP, unlike... 

Fig. 5.10 CT images in a patient with left hemiparesis. Admission CTP images show cerebral blood flow (CBF, upper left), cerebral blood volume (CBV, upper middle), and mean transit time (MTT, upper right). The presence of a matched CBF/CBV perfusion deficit suggests irreversibly ischemic infarct core , likely to correlate with DWI findings, and not a target for reperfusion therapies The admission non-contrast CT...

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