Cerebral cortex blood supply

Cerebral blood flow (CBF) was monitored in the cerebral cortex of the ischemic hemisphere corresponding to the supply territory of the middle cerebral artery by laser-doppler flowmetry (DRT4, Moor Instruments, Devon, UK). To this aim, a rectangular bent laser-doppler probe was glued onto the parietal bone (2 mm posterior and 5 mm lateral from bregma) and local CBF was continuously measured from 20 min before the onset of ischemia until 10 min after reperfusion, keeping the animal under isoflurane anaesthesia. Flow values were collected every 5 min before MCAo and after reperfusion whereas data were collected at 10 min intervals during occlusion. 

The cerebral hemispheres and diencephalon receive blood from the anterior and posterior circulations (Figure 3.5). The cerebral cortex receives its blood supply from the three cerebral arteries the anterior and middle cerebral arteries, which are part of the anterior circulation, and the posterior cerebral artery, which is part of the posterior circulation. The diencephalon, basal gan-... 

The middle cerebral artery, which originates at the division of the internal carotid artery, passes through the lateral sulcus (Sylvian fissure) en route to the lateral convexity of the cerebral hemisphere, to which it supplies blood. The middle cerebral artery travels along the surface of the insular cortex, over the inner surface of the frontal, temporal, and parietal lobes, and appears on the lateral convexity. The posterior cerebral arteries originate at the bifurcation of the basilar artery, and each one passes around the lateral margin of the midbrain. 

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