Cerebellar nuclei origin

Similar to other projections from the cerebellar nuclei (except those to the inferior olive which are GABAergic), terminals of cerebellar origin in the red nucleus are enriched in Glu (Schwarz and Schmitz, 1997 Fig. 5). Enrichment of Glu has also been detected in terminals in the oculomotor nucleus originating from the abducens and ventral lateral vestibular nuclei (Nguyen and Spencer, 1999 Fig. 5). 

The subdivision of Weidenreich-Ogawa received strong support from the localization of the fibers in the superior cerebellar peduncle. A small medial and a large lateral portion can be distinguished in this pathway in most mammals at its exit from the central nuclei (see in Fig. 102). Experiments in cat (Verhaart, 1956 Voogd, 1964) and rat (Haroian et ah, 1981) have shown that the medial part of the superior cerebellar peduncle takes its origin from the nuclei of the caudomedial group, mainly from the ipsilateral posterior interposed nucleus, and the lateral portion from the ipsilateral anterior interposed and lateral cerebellar nucleus. 

CGRP-containing neurons were double-labelled with HRP from injections in the cerebellum of the cat in the lateral reticular nucleus, the external cuneate nucleus, the descending vestibular nucleus and in the lateral and ventral divisions of the basilar pons (Bishop, 1992). The origin of a major contingent of CGRP-immunoreactive mossy fibers from the pontine nuclei may explain their preferential distribution to the cerebellar hemisphere. 

Teune TM, Van der Burg J, Ruigrok TJH (1995) Cerebellar projections to the red nucleus and inferior olive originate from separate populations of neurons in the rat a non-fluorescent double labeling study. Brain Res., 673, 313-319. 

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