Cephem dioxides allylic oxidation

A catalytic amount of palladium on charcoal (5 mol %) has been shown by Stoodley to effect allylic oxidation of cephem dioxides and (81) in yields of about 60% in each case. ... 

A related oxidative rearrangement of cephem dioxides has been reported in which an alkene is oxidized stereospecifically with rearrangement to the allylic alcohol in good yield by simple exposure to a palladium/caibon catalyst, as depicted in equation (12). Adventitious oxygen preadsotbed on the catalyst seems the likely oxida The reaction fails on the parent ccphem or its monoxide, or on the free acid of the dioxide. This reaction would seem to hold some promise for furdier utility in the cephem field and odier related systems. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

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