Cephalothin chemical structure

Semisynthetic Cephalosporins. Once the structure of cephalosporin C became known (98), attempts were made to find chemically modified analogs having superior biological properties. This was successfully achieved with the synthesis of cephalothin, cephaloridine, cephalogly-cine, and cephalexin (Figure 20). In the first two, in vitro potency was enhanced as much as 10,000 fold (99), in the latter two oral absorption... 

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