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Cephalotaxus drupacea

Paudler WW, Kerley GI, McKay J. The alkaloids of Cephalotaxus drupacea and Cephalotaxus fortunei. J. Org. Chem 1963 28 2194-2197. [Pg.1194]

Paudler W W, Kerley G I, McKay J 1963 The alkaloids of Cephalotaxus drupaceae and Cephalotaxus fortune . J Org Chem 28 2194-2197... [Pg.255]

Cephalotaxus harringtonii var. drupacea (Sieb. Zucc.) Koidz. 1930) Pinatae, Gymn., endangered Chinese tree/antitumor... [Pg.230]

Powell RG, Madrigal RV, Smith CR, Mikolajczak KL. Alkaloids of Cephalotaxus harringtonia var. drupacea. 11-Hydroxycepha-lotaxine and drupacine. J. Org. Chem. 1974 39 676-680. [Pg.1194]

Oppenauer oxidation gave the hemiketal (16). Furthermore, hydrolysis of the diacetate (14 R = R = Ac) in aqueous dioxan at ambient temperatures resulted in epimerization at C-11. All these reactions are best accommodated by the proposed stereochemical formulation (14 R = R = H) for 11-hydroxy-cephalotaxine. Interestingly, this formulation represents the most hindered of four possible geometric isomers. The alkaloids (14 R = R = H) and (15) are unique to C. harringtonia var. drupacea. It is not yet clear if drupacine (15) is identical with Alkaloid IV obtained by Asada during an extensive reinvestigation of Cephalotaxus species. ... [Pg.180]

Isolation of New Cephalotaxus Alkaloids from C. harringtonia f drupacea... [Pg.289]

Takano, I. Yasuda, M. Nishijima, Y. Hitotsuyanagi, K. Takeya, and H. Itokawa, Ester-Type Cephalotaxus Alkaloids from Cephalotaxus harringtonia var. drupacea . Phytochemistry, 1997, 44 (4), 735 - 738. [Pg.347]

Cephalotaxus Alkaloids - Four alkaloids of novel structures have been Isolated from Cephalotaxus harrlngtonla var. drupacea.29 These are cephalotax-Ine, harringtonlne, and the unnamed bases I and II. Harrlngtonlne, which Is an ester of cephalotaxlne, has shown significant Inhibitory activity against the experimental l3nnphold leukemia L-1210 and P-388 In mice. [Pg.326]

Several new alkaloids have been isolated recently from Cephalotaxus harringtonia var. drupacea, two of which, harringtonine (Va) and iso-harringtonine (Vb), show inhibitory activity against L 1210 and P388 at dose levels of 0-25 to 4 mg/kg and 0-75 to 12 mg/kg respectively [43, 44]. The structure of the heterocyclic portion of these molecules has been established [45] by spectroscopic and x-ray crystallographic studies on cephalotaxine and its methiodide, and the terpenoid portion by spectroscopic analysis of... [Pg.9]

See other pages where Cephalotaxus drupacea is mentioned: [Pg.352]    [Pg.353]    [Pg.353]    [Pg.352]    [Pg.353]    [Pg.353]    [Pg.161]    [Pg.44]    [Pg.23]    [Pg.289]    [Pg.347]    [Pg.215]    [Pg.458]   
See also in sourсe #XX -- [ Pg.552 ]



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