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Cephalosporins penicillin sulfoxide-cephalosporin ring

About one-third of the commercial cephalosporins are derived from 7-ADCA. Due to the lower cost of penicillin, 7-ADCA is usually produced from penicillin G by ring expansion of a penicillin sulfoxide ester to yield a cephalosporin ester. The removal of the ester group is followed by cleavage of the phenylacetyl side chain to give 7-ADCA. Two-thirds of the commercial cephalosporins are derived from 7-ACA, that is produced from CPC by either chemical or enzymatic deacylation. [Pg.134]

Treatment of a penicillin sulfoxide with acetic anhydride affords the cephalosporin C ring system, although with different substituents. Medically useful drugs with a modified penicillin ring system will probably be found. [Pg.20]

See other pages where Cephalosporins penicillin sulfoxide-cephalosporin ring is mentioned: [Pg.566]    [Pg.315]    [Pg.31]    [Pg.289]    [Pg.93]    [Pg.551]    [Pg.289]    [Pg.289]    [Pg.315]    [Pg.138]    [Pg.145]    [Pg.196]    [Pg.211]    [Pg.154]    [Pg.208]    [Pg.354]    [Pg.93]    [Pg.289]    [Pg.31]    [Pg.386]    [Pg.1979]    [Pg.3]    [Pg.95]    [Pg.498]    [Pg.611]    [Pg.32]    [Pg.286]    [Pg.30]    [Pg.563]    [Pg.286]    [Pg.286]    [Pg.286]    [Pg.32]    [Pg.218]    [Pg.127]    [Pg.171]   


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Penicillin sulfoxides

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