Cephalosporin Nephrotoxicity Role of Proximal Tubular Secretion

4 Cephalosporin Nephrotoxicity Role of Proximal Tubular Secretion 

Cephalosporins are broad-spectrum antibiotics similar in structure to penicillin. For several cephalosporins, therapy is limited by the development of nephrotoxicity. Cephaloridine-induced nephrotoxicity has been examined extensively in laboratory animals and is characterized by an increase in blood urea nitrogen concentration within 24-48 hr, reductions in PAFI and TEA transport, and inhibition of glucose production following treatment. 

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