Cellular retinoid-binding proteins

The specific role of vitamin A in tissue differentiation has been an active area of research. The current thinking, developed in 1979, involves initial dehvery of retinol by holo-B >V (retinol-binding protein) to the cell cytosol (66). Retinol is then ultimately oxidized to retinoic acid and binds to a specific cellular retinoid-binding protein and is transported to the nucleus. Retinoic acid is then transferred to a nuclear retinoic acid receptor (RAR), which enhances the expression of a specific region of the genome. Transcription occurs and new proteins appear during the retinoic acid-induced differentiation of cells (56). [Pg.103]

Kang S, Duell EA, Fisher GJ, et al (1995) Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. J Invest Dermatol 105 549-556... [Pg.174]

G10. Giguere, V., Retinoic acid receptors and cellular retinoid binding proteins Complex interplay in retinoic signalling. Endocr. Rev. 15, 61-79 (1994). [Pg.146]

Cellular Retinoid Binding Proteins CRBPs and CRABPs... [Pg.47]

Soprano DR (1994) Serum and cellular retinoid binding proteins. In Vitamin Receptors Vitamins and Ligands in Cell Communication, K Daksbinamurti (ed.), pp. 1-27. Cambridge, UK Cambridge University Press. [Pg.75]

Retinyl esters 102a-c (1 mCirnl ) stored under argon at —60°C in toluene containing 40 /ig of 2-t-butyl-4-methoxyphenol and 4 pL of pyridine are quite stable. After 1 year about 60% decomposition was noted, due to radiolysis in the case of 102c. Retinoic acid 103 under similar conditions is also radiochemically stable, but after 4 months the material has to be repurified. Specific activities of tritium-labelled retinoids in the 10-40 Cimmol range have been found necessary in view of the discovery and use of cellular retinoid binding proteins. ... [Pg.809]

Ruberte, E., Dolle, P., Chambon, P., Morriss-Kay, G. 1991a. Retinoic acid receptors and cellular retinoid binding proteins II. Their differential pattern of transcription during early morphogenesis in mouse embryos. Development 111, 45-60. [Pg.203]

El Akawi, Z. and Napoli, J. L (1994) Rat liver cytosolic retinal dehydrogenase, comparison of 13-cw-, 9-cis-, and all-trans-retinal as substrates and effects of cellular retinoid-binding proteins and retinoic acid on activity. Biochemistry 33, 1938-1943... [Pg.42]

Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) for Cellular Retinoid-Binding Proteins... [Pg.81]

Loughney, A. D, Kumarendran, M K., Thomas, E. J., and Redfern, C P. F. (1995) Variation in the expression of cellular retinoid-binding proteins in human endometrium throughout the menstrual-cycle. Hum Reprod 10, 1297-1304... [Pg.88]

Saari, J. C., Bredburg, L, and Garwin, G. G. (1982) Identification of the endogenous retinoids associated with three cellular retinoid-binding proteins from bovine retina and retinal pigment epithelium J Biol. Chem 257, 13,329-13,333. [Pg.103]

Detection of Conformational Changes in Cellular Retinoid-Binding Proteins by Limited Proteolysis... [Pg.165]

Ross, A C. (1993) Cellular metabolism and activation of retinoids roles of cellular retinoid-binding proteins FASEB J 7,317-327... [Pg.328]

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