Celecoxib absorption

A study in 50 children showed that a single 250-mg/m dose of celecoxib, given with high-fat food, increased the maximum plasma concentration by 82% and the AUC by 60%. When steady-state levels were achieved with celecoxib 250 mg/m twice daily, food increased the maximum plasma concentration by 99% and the AUC by 75%. The manufacturers of celecoxib note that a high-fat meal delayed absorption by about one to 2 hours and the total absorption was increased by 10% to 20%. ... 

Although food delayed the absorption of celecoxib, the UK manufacturer says that it can be taken with or without food. However, high-fat food may increase the total absorption of celecoxib and the US manufacturer suggests that higher doses (400 mg twice daily) should be administered with food to improve absorption. ... 

Morgen, M., Bloom, C., Beyerinck, R., Bello, A., Song, W., Wilkinson, K., Steenwyk, R., Shamblin, S. Polymerie nanoparticles for increased oral bioavailability and rapid absorption using celecoxib as a model of a low-solubility, high-permeability drug. Pharm. Res. 2012, 29(2), 427—440. 

Guzmdn, H.R. Tawa, M. Zhang, Z. Ratanabanangkoon, P. Shaw, P. Gardner, C.R. Chen, H. Moreau, J.P. Almarsson, O. Remenar, J.F. Combined use of crystalline salt forms and precipitation inhibitors to improve oral absorption of celecoxib from solid oral formulations. J. Pharm. Sci. 2007, 96(10), 2686-2702. 

S. Paulson, M. Vaughn, S. lessen, Y. Lawal, C. Gresk, B. Yan, T. Maziasz, C. Cook, and A. Karim, Pharmacokinetics of celecoxib after oral administration in dogs and humans effect of food and site of absorption, J. Pharmacol. Exp. Ther., 297, 638-645 (2001). 

Yener, G. GonuUu, U. Uner, M. Degim, T. Araman, A. Effect of vehicles and penetration enhancers on the in vitro percutsineous absorption of celecoxib through hiunan skin, Pharmazie, 2003,58, 330-333. 

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