Ferrous sulfate Cefdinir

Ferrous sulfate marked reduces the absorption of cefdinir. Clinical evidence... 

When 6 healthy subjects were given ferrous sulfate (1050 mg of Fero-Gradumet, sustained release, equivalent to 210 mg of elemental iron) with cefdinir 200 mg the AUC of the cefdinir was reduced by 93%. When the ferrous sulfate was taken 3 hours after the cefdinir, the absorption of the cefdinir remained unchanged for 3 hours and then rapidly fell, the total AUC over 12 hours being reduced by 36%. ... 

It is believed that the ferrous sulfate chelates with the cefdinir in the gut to produce a poorly absorbed complex. 

An established interaction of clinical importance. Avoid ferrous sulfate and other iron compounds while taking cefdinir. It is not yet known how far apart these drugs must be separated to avoid this interaction, but 3 hours improves the situation considerably even if it does not totally solve it. There is no information to suggest that other eephalosporins interact in this way. 

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See also in sourсe #XX -- [ ]

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