CDP microspheres

/3-CD is dissolved in 20% NaOH aqueous solution, then EPI is dropped in with stiring. The mixture reacts for 1.5 h at room temperature, and then 200 kerosene which contains emulsifier (n (tween 20) n (span 80) = 1 3) is added and vigorously mixed for 5 min to make the water phase disperse. Finally, the reaction system is heated up to 60° C, stirring speed is reduced while continuing to react for 8 h. The product is filtered and washed with diluted hydrochloric acid, methanol, distilled water and acetone, respectively. After wash, the product is dried imder vacuum. 

At present, CDP which is used in medication control release is a hot research direction in CD science. Relevant reports are limited, especially the study on control release of traditional Chinese medicine. Researches in which j8-CDP is used as microspheres to control the release of medicine are important for development of new form and modernization of traditional Chinese medicine. 

Some researchers prepared magnetic polymer microsphere using -CD which included magnetic material by crosslinking method [37]. 

Magnetic polymer microsphere is a kind of microspheres which combines inorganic polymer and magnetic materials. It is magnetic and surface modifiable, therefore, has a wide application in the targeted drugs, immobilized enzyme and cell separation, etc. 

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