CDC Reactions Involving Alkane C-H Bonds

Cross-Dehydrogenative-Coupling Reactions Involving Allyl, Benzyl and Allq/l C-H Bonds 103 

Air-sensitive phosphine ligands are rarely used for CDC reactions under strong oxidative conditions. However, the Li group developed a 

Similarly, purines were able to couple with simple alkanes in the presence of peroxides. Guo and co-workers found that the reaction occurred on C8 to give C8-alkylpurines by C-C bond formation that was only promoted by TBP, while it occurred on the amino group to give N6-allqzlated purines by C-N 

Antonchick and co-workers found that [bis(trifluoroacetoxy)iodo]benzene (FIFA) and NaNj could be used as an alternative radical initiator in the absence of a transition metal catalyst. Various nitrogen-containing hetero-arenes were reacted with simple alkanes in the presence of FIFA and NaNg to 

---