CD52 antigen

The CD52 antigen, a 21- to 28-kDa glycopeptide, is expressed at high density on the surface of B- and T-l5miphocytes, macrophages, and monocytes, but not hematopoietic stem cells (33). It is also expressed on all CLL cells and indolent B-cell lymphoma cells. The entire structure of the CD52 molecule has been determined. However, its function still remains to be revealed. 

SYNTHESIS OF A HUMAN SPERM CD52 ANTIGEN GPI ANCHOR... 

SCHEME 13.21 Completion of Guo s synthesis of the CD52 antigen GPI anchor 141. 

Figure 2. Structures of synthetic CD52 antigen carrying natural glycans...

Scheme 6 Solid-phase synthesis of CD52 antigen.

Scheme 10 Convergent assembly of the GPI anchor of sperm CD52 antigen.

Some anchors contain an additional fatty acid that is ester linked to the 2-hydroxyl group of the w> o-inositol. Examples are human erythrocyte acetylcholinesterase [24], T. brucei PARP [16, 25] (Figure 1C), and a population of the human CD52 antigen [19], In some inositol-acylated proteins this acyl chain is a palmitate whereas in some others (e.g. PARP) mass spectrometry analysis has showed that it is quite heterogeneous, containing a mixture of fatty acids (Figure 1C) [16]. 

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