Cavity surface error correction

The combinatorial term Pcomb(X,S) in Eq. (11) denotes a usually small correction for size and somewhat also for shape dilferences of the solutes and solvents, which is reasonably well understood from chemical engineering models. It is an empirical function, depending only on the surface areas and volumes of solute and solvent molecules, which are reasonably known from the COSMO cavities. The error arising from the approximations made in the combinatorial term can be expected to be much less than IkJ mol, or 0.17 log units, and hence can be safely neglected in the context of drug solubiUty estimation. 

Calculating the temperature control error (temperature differences on the cavity surface) and possible correction of the channel layout. 

Piezoelectric cavity pressure sensors are suitable for direct use in the cavity due to their physical properties. They are usually installed flush with the mold wall and can be adjusted to the surface by spark erosion or grinding of the sensor front. If installed correctly while maintaining the required drilling tolerances, an error-free measurement of the cavity pressure can be assumed. 

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