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Cationic intermediates direct trifluoromethylation

Why IS there such a marked difference between methyl and trifluoromethyl substituents m their influence on electrophilic aromatic substitution s Methyl is activating and ortho para directing trifluoromethyl is deactivating and meta directing The first point to remember is that the regioselectivity of substitution is set once the cyclohexadienyl cation intermediate is formed If we can explain why... [Pg.489]


See other pages where Cationic intermediates direct trifluoromethylation is mentioned: [Pg.855]    [Pg.596]    [Pg.43]    [Pg.105]    [Pg.291]    [Pg.190]    [Pg.702]   
See also in sourсe #XX -- [ Pg.776 , Pg.777 , Pg.778 , Pg.779 ]




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Cation intermediate

Intermediate cationic

Trifluoromethyl cation

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