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Cathepsin structure-activity relationship

More detailed studies of epimerization in the azepanone series indicated that these compounds were configurationally stable over a pharmaceutically relevant time-scale [19]. Structure-activity relationships developed in previous series were applied successfully to the azepanone scaffold, yielding extremely potent enzyme inhibitors that exhibited good diastereomeric selectivity as well as reasonable selectivity versus cathepsin K homologues. [Pg.138]

See other pages where Cathepsin structure-activity relationship is mentioned: [Pg.40]    [Pg.148]    [Pg.35]    [Pg.1284]    [Pg.228]    [Pg.76]    [Pg.1284]    [Pg.163]    [Pg.42]   
See also in sourсe #XX -- [ Pg.6 , Pg.185 ]



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Cathepsins

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