Catecholamines dynamics

The in vitro data and the results from this clinical trial were synthesized in a so-called dynamic model of receptor kinetics by Liggett [72]. According to this theory, Gly/Gly homozygous individuals are already down-regulated as a result of exposure to endogenous catecholamines. Thus, the recurring exogenous exposure to... 

Becker JB, Ramirez VD (1980) Dynamics of endogenous catecholamine release from brain fragments of male and female rats. Neuroendocrinology 31(1) 18-25 Beckett AH, Gorrod JW, et al (1971) The effect of smoking on nicotine metabolism in vivo in man. 1 Pharm Pharmacol 23 62S-67S... 

Nechaev, I.V., Pavlov, D.S., Labas, Yu.A. and Legky, B.P. (1991). Dynamics of catecholamines in early ontogeny and the development of behavioural reactions in juvenile Aequidespulcher fry. Voprosy Ikhtiologii 31,822-838. 

Britz-McKibbin, P. and Chen, D.D.Y., Selective focusing of catecholamines and weakly acidic compounds by capillary electrophoresis using a dynamic pH junction. Anal. Chem., 72, 1242, 2000. 

Electrochemical detection in HPLC has become established for some, more specialized, applications such as catecholamine analysis though it can be exploited for a far wider range of compounds. The work in this paper has attempted to investigate some of the basic properties of an electrochemical detection system and some more difficult applications. The detector has a linear dynamic range and precision that are comparable with those of other detectors for HPLC. It is, however, more dependent on temperature than, for example, the UV absorption detector and must be operated in a temperature controlled environment to obtain the lowest detection limits. For many electroactive compounds with moderate oxidation potentials, the electrochemical detector can yield sub-nanogram detection limits. 

Barthohni, G., Stadler, H., Ciria, M.G. and Lloyd, K.G., Use of push-pull cannula to estimate dynamics of acetylcholine and catecholamines within various brain areas. Neuwpharmacology, 15, 515-519 (1976). 

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