Catalytic system adamantyl

Aryl coupling reactions. A highly active catalytic system for Suzuki coupling contains Pd(OAc)2, KF, and di-/-butyl-2-biphenylphosphine. but the most efficient catalyst to date is the combination of Pd(OAc)2 and bis(l-adamantyl)butylphosphine, which is effective to couple deactivated AiCl on very low Pd loading (down to 0.001 mol%) yet showing turnover number in the 10,(X)0-20,(XX) range. Products are obtained in good yields. 

Ackermaim showed in 2005 that phosphine oxide R2P(0)H additives efficiently activate the ruthenium(ll) catalyst, which allowed the direct C-H bond arylation with the less reactive but readily available arylchlorides, such as (adamantyl)2-P(0)H (Ad2P(0)H) associated with [RuCl2(p-cymene)]2 (Scheme 2) [44]. This catalytic system was used for the monoarylation with arylchlorides of ketimines to... 

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