Catalyst-Free Strecker Reactions in Water

The original protocol of a one-pot Strecker reaction was performed in water as reaction solvent, but in subsequent procedures, water has been replaced by organic solvents, such as toluene, dichloromethane, and acetonitrile, or nonconventional solvent, such as ionic liquid [68], especially with TMSCN as cyanide source, to improve the solubility of organic reagents. Although there are also examples performed in aqueous media [69], including water-containing DMF [70], polyethylene 

SCHEME 10.22 Synthesis of functionalized a-aminonitriles 68 via multicomponent tandem S AA reaction. 

SCHEME 10.23 Synthesis of a-methylene-y-butyrolactam 69a via SAAC strategy. 

SCHEME 10.25 Ga(OTf)3-catalyzed Strecker reaction using ketones. 

Rl = Ar R2 = Ar, alkyl SCHEME 10.26 Multicomponent Strecker synthesis of ketones catalyzed by Fe(Cp)2PFg. 

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P. Galletti, M. Pori, D. Giacomini, Eur. J. Org. Chem. 2011, 3896-3903. Catalyst-free Strecker reaction in water a simple and efficient protocol using acetone cyanohydrin as cyanide... 

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