Dexamethasone Caspofungin

CASPOFUNGIN DEXAMETHASONE i caspofungin levels, with risk of therapeutic failure Induction of caspofungin metabolism t dose of caspofungin to 70 mg daily... 

Concomitant medication with inducers of drug c/earance. Patients on rifampin should receive caspofungin 70 mg/day. Patients on nevirapine, efavirenz, carbamazepine, dexamethasone, or phenytoin may require an increase in dosage to caspofungin 70 mg/day. 

Carbamazepine, dexamethasone, efavirenz, nevirapine, phenytoin, rifabutin, rifampin may decrease caspofungin levels... 

Rifampicin modestly reduces the trough levels of caspofungin after 2 weeks of concurrent use, but this is not thought to be due to increased metabolism. One case of caspofungin treatment failure has been reported in a patient taking rifampicin. Other enzyme inducers (carbamazepine, dexamethasone, efavirenz, nevirapine, and phenytoin) also appeared to reduce caspofungin levels. Rifampicin and other unnamed enzyme inducers did not appear to alter anidulafungin clearance. 

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