Ciclosporin Caspofungin

CASPOFUNGIN CICLOSPORIN 1.1 plasma concentrations of cidosporin, with risk of transplant rejection 2. Enhanced toxic effects of caspofungin and T alanine transaminase levels 1. Due to induction of metabolism of cidosporin by these drugs. The potency of induction varies 2. Uncertain 1. Monitor for signs of rejection of transplants. Monitor cidosporin levels to ensure adequate therapeutic concentrations and t dose when necessary 2. Monitor LFTs... 

Ciclosporin appears to modestly increase caspofungin levels, and concurrent use can apparently result in raised liver enzymes. Ciclosporin slightly raised anidulafungin levels in one study, without any serious adverse events. 

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