Cascades Initiated by Hetero-Michael Reaction

Hetero-Michael/aldol cascade reactions have been studied by several research groups using ort/zo-substituted benzaldehydes as functionalized reagents. In this context, different benzo-fused heterocyclic architectures have 

Related to this topic, our group has also developed an interesting cascade process for the enantioselective synthesis of furofuranes in a single step by the 31a-catalyzed reaction between dihydroxyacetone dimer and a,p-unsaturated 

Finally, it has to be pointed out that the enantioselective epoxidation of a,p-unsaturated compounds with peroxides can also be considered to happen via a 

Alternatively, the epoxidation of enones has also been covered using primary amine catalyst 28c or by applying the asymmetric counterion-directed 

---