Cascade Reaction-Merging Iminium and Enamine Catalysis

Cascade Reaction-Merging Iminium and Enamine Catalysis [Pg.86]

The discovery of two discrete amine catalysts that can increase selectivities in each step of this cascade reaction represents a further milestone of this development and has led to a more modulated stereoselective appUcation of these cascade reactions. Practically enantiomerically pure syn- or anti-configured aldehydes can be accessed by a careful combination of two different imidazoUdin-4-ones. The usefulness of this concept was demonstrated by the MacMiUan group in several important transformations. [Pg.87]

4 Cascade Reaction-Merging tminium and Enamine Catalysis 89 fiu02C . /C02fiu [Pg.89]

In a second series the same authors realized cascade reactions of conjugate addition/amination reactions. The corresponding highly substituted aldehydes 88 [Pg.90]

To demonstrate the power of this concept the sesquiterpene (-)-aromadendran-ediol was synthesized by the same authors using this cascade enamine-iminium activation concept. [Pg.90]

For a merged metal catalyzed (cross-metathesis) and organocatalyzed (iminium/ enamine) cascade reaction see Reference [111]. [Pg.90]

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