Carisoprodol toxicity

As carisoprodol and its metabolite meprobamate are GABA receptor agonists, the use of the benzodiazepine receptor antagonist flumazenil might be considered in some cases of carisoprodol toxicity (5). 

Various drugs have been used to treat muscle spasm. Most compounds in this group act as simple sedative-hypnotic agents and produce skeletal muscle relaxation indirectly. The drugs commonly used as skeletal muscle relaxants are listed in Table 11-53. Carisoprodol (Soma ) and baclofen have been abused as recreational drugs. I. Mechanism of toxicity... 

II. Toxic dose. The toxic dose varies considerably between dmgs, depends largely on individual tolerance, and can be influenced by the presence of other drugs such as ethanol. For most of these dmgs, ingestion of more than 3-5 times the usual therapeutic dose may cause stupor or coma. Death was reported in a 4-year-old who ingested approximately 3500 mg of carisoprodol. 

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See also in sourсe #XX -- [ , ]

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