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Cardiovascular Safety Pharmacology

Conscious Dogs and Other Species. 65 I.D.2.2 Cardiovascular Safety [Pg.61]

Regulatory guidance for non-clinical cardiovascular safety pharmacology testing is given in the ICH S7A and B.25,42 The effects of an NCE on blood pressure, heart rate, and the ECG should be evaluated. Furthermore, in vivo, in vitro, and ex vivo evaluations, including methods for (assessing) repolarization and conductance abnormalities, should... [Pg.256]

Chiang, A.Y., Smith, W.C., Main, B.W., and Sarazan, R.D., Statistical power analysis for hemodynamic cardiovascular safety pharmacology studies in beagle dogs, /. Pharmacol. [Pg.281]

I.D.2 In vivo Experimental Models for Cardiovascular Safety Pharmacology... [Pg.65]

Similar telemetry-based cardiovascular safety pharmacology studies can be conducted in pigs and monkeys (normally macaca mulatto (Rhesus) or macaca fascicu-laris (Cynomulgus)). These two alternative species are of interest due to their use in toxicology studies where... [Pg.67]

Markert M, Klumpp A, Trautmann T, Guth BD (2004) A novel propellant-free inhalation drug delivery system for cardiovascular safety pharmacology evaluations in dogs. Journal of Pharmacological and toxicological Methods 50 109-119... [Pg.68]

Cardiovascular Safety Pharmacology Studies in Anesthetized Dogs and Other Species... [Pg.68]

See other pages where Cardiovascular Safety Pharmacology is mentioned: [Pg.743]    [Pg.259]    [Pg.282]    [Pg.318]    [Pg.344]    [Pg.16]    [Pg.61]    [Pg.61]    [Pg.62]    [Pg.62]    [Pg.62]    [Pg.63]    [Pg.63]    [Pg.63]    [Pg.64]    [Pg.64]    [Pg.64]    [Pg.64]    [Pg.65]    [Pg.66]    [Pg.67]    [Pg.68]    [Pg.70]    [Pg.72]    [Pg.72]    [Pg.73]    [Pg.74]    [Pg.75]    [Pg.76]    [Pg.77]    [Pg.78]    [Pg.79]    [Pg.80]    [Pg.81]    [Pg.82]    [Pg.83]    [Pg.84]    [Pg.86]    [Pg.88]    [Pg.90]    [Pg.92]    [Pg.94]   


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Cardiovascular Safety Pharmacology Studies in Anesthetized Dogs and Other Species

Cardiovascular pharmacology

Cardiovascular safety

Cardiovascular safety pharmacology core battery

In vitro Cardiovascular Safety Pharmacology Models

In vivo Experimental Models for Cardiovascular Safety Pharmacology

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