Cardiotonic peptides

Canthine skeleton 52 Cardiotonic agent, heart failiu-e 3 Caspase-3 inhibitors, non-peptide 269 Catch and release , 2,4,5-trisubstituted pyrimidines 98 Chloro dehydroxylation 17 Click chemistry, 1,4-disubstituted triazoles 45... 

When AP-A was treated with trypsin only the Argl4 to Glyl5 peptide bond was cleaved [56]. The resulting derivative lacked cardiotonic activity but its binding affinity for the rat brain sodium channel was reduced by less than an order of magnitude (Llewellyn LE et al., unpublished results). Its overall structure, as... 

Figure 35. 8-Casomorphin peptide messenger in addressing opioid and cardiovascular-cardiotonic (modulatory) subroutines of general psychoneuroimmuno-logical programs, superimposed with organizational microstate [72 d] distributions and simplified regulation schemes of heart muscle contractions [ 18, 36, 52 y, z].

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