Cardiotonic agent, heart failure

Fig. 1 Heterocycles bearing a 2-pyridone moiety with wide range of medicinal applications. Amrinone WIN 40680 1 is a cardiotonic agent for the treatment of heart failure. ZAR-NESTRA 2 is a selective farnesyl protein inhibitor and NP048 3 is a pilicide with novel antibacterial properties. The 2-pyridones 4, 5 and 6 are schematic representations of the three categories of 2-pyridones that wiU be covered in this chapter i.e., substituted 2-pyridones 4, 2-quinolones 5 and other ring-fused 2-pyridones 6...

The discovery of the positive inotropic and systemic vasodilator activities of bipyridine-derived compounds, like amrinone (7) and milrinone (8), has markedly stimulated research aimed at the development of structurally related non-steroidal, non-catecholamine cardiotonics. In this context, a wide variety of pyridazinone derivatives have been prepared and investigated in search for novel agents useful for the chronic management of congestive heart failure. 

Martin IL, Likoff MI, Ianicki IS, Laskey WK, Hirshfeld JW Jr, Weber KT. Myocardial energetics and clinical response to the cardiotonic agent MDL 17043 in advanced heart failure. J Am Coll Cardiol 1984 4(5) 875-83. 

J. A. Bristol, I. Sircar, W. H. Moos, D. B. Evans, and R. E. Weishaar, /. Med. Chem., 27, 1099 (1984). Cardiotonic Agents. 1. 4,5-Dihydro-6-[4-(lH-imidazol-l-yl)phenyl]-3(2H)-pyri-dazines Novel Positive Inotropic Agents for the Treatment of Congestive Heart Failure. 

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